All lanes of the Pali Highway are closed because of three landslides near the tunnels.
The State Department of Transportation says the closure will continue through the Tuesday morning commute.
The first landslide happened around 4 p.m. Monday in the Kailua bound lanes.
Fortunately, no one was hurt.
But a few minutes later, a second landslide happened in the Honolulu bound direction.
At least two vehicles were damaged, including a truck.
Honolulu emergency officials treated a 43-year-old woman who was injured by fallen rocks and mud.
She was sitting in the back of the truck.
A nine-year-old girl and two-year-old girl were also hospitalized in stable condition.
A third landslide in the Honolulu bound direction of the highway was reported around 7 p.m.