Traffic is backed up on the H-3 Freeway following a crash involving multiple vehicles.
It happened in the west, or town-bound, lanes, near Halawa just before 5 p.m.
According to Emergency Medical Services, the crash involved a large container truck.
Paramedics treated and transported three patients to the hospital.
A man and woman, both in their 30s, were listed in serious condition. A man in his 40s is listed in stable condition.