The H-2 Freeway going south near Mililani was reopened at 3 p.m. after an auto accident closed it two hours before.
Witnesses say two vehicles were involved, including an SUV that flipped over after striking a stalled vehicle in the middle southbound lane.
According to Emergency Medical Services officials, a 30-year-old woman, a 31-year-old man and a 9-year-old boy were all taken to the Queen's Medical Center in serious condition.